Subependymal Giant Cell Astrocytoma SEGA

WHO grade I

Synonyms:

a.k.a. SGCA

Diagnosis:

Suggested by MRI and confirmed by pathology (brain biopsy/resection)

Findings on Investigations:

CT: Near foramina of Monro, may block it, extends intraventricularly, enhances, may calcify
MRI: Near foramina of Monro, may block it, extends intraventricularly, enhances
Pathology:
Histology: large cells resembling gemistocytic astrocytes with neuron-like nuclei & astrocyte-like cytoplasm, calcifications may be present. Perivascular pseudorosettes.
Immunohistochemistry: Positive for GFAP, S100
Associated with tuberous sclerosis

Treatment:

Surgical Resection
Stereotactic radiotherapy: Gamma knife
mTOR inhibitors:

  • Everolimus
  • Rapamycin (sirolimus)

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