Diagnosis:
Clincial features, exposure to solvent and MRI
Clinical features:
Solvent exposure
Rapidly progressive dementia, akinetic mute, other features
Findings on Investigations:
MRI:
- Diffuse symmetric involvement of white matter
Pathology:
PAS-positive macrophages
Electron microscopy EM: membrane-bound lamellar material within macrophage
Treatment:
Supportive care