Synonyms:
Lewis Sumner syndrome LSS
Diagnosis:
Clinical features supported by +NCS/EMG
Clinical features:
Chronic, asymmetric, distal, sensorimotor, arms >legs, can affect cranial nerves
Findings on investigations:
NCS/EMG:
- Multifocal conduction block in affected nerves,
- Widespread sensory abnormalities: helps distinguish from MMN,
- Asymmetric, helps distinguish it from CIDP
- Serum anti-GM1 antibody: negative, helps distinguish from MMN
CSF: raised protein occasionally
Treatment:
Intravenous immunoglobulin IVIg 2 g/kg over 3–5 days once a month for 2 months,
Prednisolone 1 mg/kg/day for 4 weeks then taper for 6 weeks